Frequency and types of nail changes in patients of vitiligo
DOI:
https://doi.org/10.66344/jpad.v31i2.1608Abstract
Background Nail involvement is frequently observed in various dermatoses including psoriasis, lichen planus, and alopecia areata. Vitiligo affects 0.1-4% of global population. It is associated with other autoimmune disorders having nail abnormalities. The frequency and nature of nail abnormalities in vitiligo are not known in our local population.
Objective To determine the frequency and types of nail changes in patients of vitiligo.
Methods This cross-sectional study was conducted in the Dermatology outpatient department of Jinnah Hospital Lahore, Pakistan for duration of six months. 240 cases of vitiligo, of both genders, ages between 15-50 years and with any duration of disease were enrolled.
Results In our study population of 240 cases, 150 cases (62.5%) of vitiligo had nail changes. 40.67% (n=61) had longitudinal ridging, 12.67% (n=19) had leukonychia, 10.67% (n=16) had absent lunula, 5.33% (n=8) had trachonychia, 4.67% (n=7) had onycholysis, 4.67% (n=7) had clubbing and 4% (n=6) had splinter hemorrhages.
Conclusion Nail changes were observed in more than sixty percent cases of vitiligo. Longitudinal ridging was the most common type of nail abnormality followed by leukonychia and absent lunula.
References
1. SchildM, Meurer M. Vitiligo: Clinical presentation and pathogenesis. Hautarzt. 2016;67(2):173-86.
2. Topal IO, Gunjor S, Kocaturk OE, Duman H. Nail abnormalities in patients with Vitiligo. An Bras Dermatol. 2016;91(4): 442–5.
3. Dillon AB, Sideris A, Hadi A, Elbuluk N. Advances in Vitiligo: An Update on Medical and Surgical Treatments. J Clin Aesthet Dermatol. 2017;10(1):15–28.
4. Diaz EA, Perez EA, Rodriquez MR, Tovar MG et al. Autoimmune vitiligo in rheumatic disease in the mestizo Mexican population. Biomed Rep. 2016;5(2):176–80.
5. Sandoval-Cruz M, García-Carrasco M, Sánchez-Porras R, Mendoza-Pinto C et al. Immunopathogenesis of vitiligo. Autoimmun Rev. 2011;10(12):762-5.
6. Rich P, Scher RK. Nail anatomy and basic science. In: An Atlas of Diseases of the Nail, Parthenon Publishing, New York 2003;7.
7. Myers KA, Farquhar DR. The rational clinical examination. Does this patient have clubbing? JAMA.2001;286:341–7.
8. Mercy K, Kwasny M, Cordoro KM. Clinical manifestations of pediatric psoriasis: results of a multicenter study in the United States. Pediatr Dermatol. 2013;30:424.
9. Anbar T, Hay RA, Abdel-Rahman AT, Moftah NH, Al-Khayyat MA. Clinical study of nail changes in vitiligo. J Cosmet Dermatol. 2013;12:67–72.
10. Milligan A, Barth JH, Graham-Brown RA, Dawber RP. Pseudo-mycotic nail dystrophy and vitiligo. Clin Exp Dermatol. 1988; 13:109-10.
11. Barth JH, Telfer NR, Dawber RP. Nail abnormalities and autoimmunity. J Am Acad Dermatol. 1988;18:1062-5.
12. Khandpur S, Reddy BS. An association of twenty-nail dystrophy with vitiligo. J Dermatol. 2001;28:38–42.
13. Bodman MA. Nail dystrophies. Clin Podiatr Med Surg. 2004;21:663-87.
14. Tosti A, Morelli R, Bardazzi F, Peluso AM. Prevalence of nail abnormalities in children with alopecia areata. Pediatr Dermatol. 1994;11:112–15.
Downloads
Published
Issue
Section
License
Copyright (c) 2021 MAHEEN IRFAN, Nadia Ali Azfar, Amna Rasul, Aisha Chaudhry, Zartaj Liaqat, Ambreen Ashraf
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
