Disseminated cutaneous leiomyoma in a young male: A case report
DOI:
https://doi.org/10.66344/jpad.28.4.2018.1318Keywords:
Leiomyomas, nodules, disseminated patternAbstract
Leiomyomas are rare benign tumours, arising most commonly from the arrector pili muscles (pilar leiomyomas), from tunica media of blood vessels (angioleiomyomas) or from genital skin muscles (dartoic leiomyomas). We report a case of disseminated cutaneous leiomyoma in a 26-year-old Asian male who presented with multiple red and dusty brown coloured firm nodules on his upper chest, left arm, left leg and upper back. The case was diagnosed on dermatopathology and with immunohistochemical studies. Considering the widespread disease, surgical excision was not possible. Patient improved symptomatically with pregablin and is under regular follow-up. We report this case because cutaneous leiomyoma is a rare disease and it usually does not present in a disseminated pattern.  ÂReferences
Badaloe S, Van Geel M, Van Steensel MA, Bastida J, Ferrando J, Ferris LK et al. Diffuse and segmental variants of cutaneous leiomyomatosis: novel mutations in the fumarate hydratase gene and review of the literature. Exp Dermatol. 2006;15:735-41.
Lehtonen HJ. Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics. Fam Cancer. 2011;10:397.
Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406.
Matthews JH, Pichardo RO, Hitchcock MG, Leshin B. Cutaneous leiomyoma with cytologic atypia, akin to uterine symplastic leiomyoma. Dermatol Surg. 2004;30:1249-51.
Pissoat L, Megahed M. Disseminated cutaneous leiomyomas. Hautarzt. 2012;63:363-5.
Raj S, Calonje E, Kraus M, et al. Cutaneous pilar leiomyoma: clinicopathologic analysis of 53 lesions in 45 patients. Am J Dermatopathol. 1997;19:2.
Christenson LJ, Smith K, Arpey CJ. Treatment of multiple cutaneous leiomyomas with CO2 laser ablation. Dermatol Surg. 2000;26:319-22.
Dilek N, Yuksel D, Sehitoglu I Saral Y. Cutaneous leiomyoma in a child: A case report. Oncol Lett. 2013;5:1163-4.
Bari AU. Zosteriform Cutaneous Leiomyoma: A Rare Cutaneous Neoplasm. J Coll Physicians Surg. 2012;23:586-7.
Bandyopadhyay D, Saha A, Bhattacharya S. Bilateral Multisegmental Zosteriform Leiomyoma Cutis: A Rare Entity. Indian J Dermatol. 2015;60:293-5.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.