Squamous cell carcinoma over lower limb in an Indian patient with disseminated discoid lupus erythematosus


  • Shashank Bhargava R. D. GARDI MEDICAL COLLEGE
  • Ujjwal Kumar
  • Krishnendra Varma
  • Richa Rokde


Squamous cell carcinoma, disseminated, discoid lupus erythematosus


Disseminated discoid lupus erythematosus (DLE) is a subtype of DLE when the typical lesions are found below the neck. Squamous cell carcinoma being a very rare complication of discoid lupus erythematosus in India. It is usually seen over the scalp, lips, cheek or ears. Case report: A 54 year old woman presented 2 years back with multiple scaly lesions with dark colored borders over the lower limbs. She gave history of such lesions since last 12 years. She was then diagnosed with DLE, she now presented with asymptomatic growths over the right leg since last 1 year. On examina­tion, there were multiple vegetative plaques over the right lower limb which had central ulceration. They were non tender and with no local rise of temperature. The inguinal and femoral groups of lymph nodes were not enlarged. Histopathological examination revealed hyperkeratosis, papillomatosis, keratin pearls and malignant atypical cells invading dermis arranged in cords and sheets, the features were consistent with that of a well differentiated SCC. We evaluated our case of disseminated DLE for any progression to systemic lupus erythematosus with no systemic involvement. She was referred to an onco-surgeon for excision. 


Liu W, Shen ZY, Wang LJ, et al. Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases. Histopathology 2011; 59: 292-8.

Goodfield MJ, Dutz J, McCourt C. Lupus Erythematosus (Discoid Lupus Erythematosus). In: Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook's Textbook of Dermatology, 9th ed. Oxford: Blackwell Science Ltd; 2016. p. 51. 2-11.

Millard LG, Barker DJ. Development of squamous cell carcinoma in chronic discoid lupus erythematosus. Clin Exp Dermatol 1978; 3: 161-6.

Grossman D, Leffell DJ. Squamous Cell Carcinoma. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick's Dermatology in general medicine. 8th ed. New York: McGrawHill; 2012. p.1285-94.

Kar BR, Nair V, Ebenezer G, Job CK. Squamous cell carcinoma of the scalp arising from chronic cutaneous lupus erythematosus: report of two Indian patients. Indian J Dermatol Venereol Leprol 2004; 70: 236-8.

Dawn G, Kanwar AJ, Dhar S, Nanda R. Squamous Cell Carcinoma over Disseminated Discoid Lupus Erythmatosus on Non-photoexposed Skin. Ind J Dermatol Venereol Leprol 1994; 60: 217-8.

Kim DY, Rha EY, Yoo G, Lim JS. Squamous cell carcinoma on the upper lip of a patient with discoid lupus erythematosus. Arch Plast Surg 2013; 40: 155-7.

Makita E, Akasaka E, Sakuraba Y, Korekawa A, Aizu T, Kaneko T et al. Squamous cell carcinoma on the lip arising from discoid lupus erythematosus: a case report and review of Japanese patients. Eur J Dermatol 2016; 26: 395-6.

Molomo EM, Bouckaert M, Khammissa RA, Motswaledi HM, Lemmer J, Feller L. Discoid lupus erythematosus-related squamous cell carcinoma of the lip in an HIV-seropositive black male. J Cancer Res Ther 2015; 11: 1036.

Shapera EA, Kim PD. Squamous Cell Cancer Arising in an African American Male Cheek from Discoid Lupus: A Rare Case and Review of the Literature. Case Rep Surg 2016; 7: 1-3.

J. K. Simpson, R.Medina-Flores, and J.-S.Deng, “Squamous cell carcinoma arising in discoid lupus erythematosus lesions of the ears infected with human papillomavirus,” Cutis 2010; 86: 195-8.

Bhat MR, Hulmani M, Dandakeri S, Kambil SM, Gatti R. Disseminated discoid lupus erythematosus leading to squamous cell carcinoma. Indian J Dermatol 2012; 57: 158-61.

Fernandes MS, Girisha BS, Viswanathan N, Sripathi H, Noronha TM. Discoid lupus erythematosus with squamous cell carcinoma: a case report and review of the literature in Indian patients. Lupus. 2015; 24: 1562-6.




How to Cite

Bhargava S, Kumar U, Varma K, Rokde R. Squamous cell carcinoma over lower limb in an Indian patient with disseminated discoid lupus erythematosus. J Pak Assoc Dermatol [Internet]. 2019Sep.1 [cited 2024Feb.26];29(1):130-3. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1223



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