Silicon level in skin tissues of normal female individuals


  • Ago Harlim
  • Siti Aisah
  • Riwandi Sihombing


Silicon, skin, topical, accumulation


Objective To evaluate silicon level in normal skin tissue. Methods The silicon levels in skin samples were measured using an atomic absorbance spectrophotometer in 37 healthy normal females who had never received silicone injection and compared with those who had developed granuloma after silicone injection.. Results Low silicon level (44.07±75.86 µg/g) was found in skin tissues of normal individuals as compared to those who developed post-silicone granuloma (1709.21±1851.72 µg/g). Conclusion Silicon may be found in normal skin tissue due to daily use of cosmetic products; however the level is significantly low.


Price CT, Koval KJ, Langford JR. Silicon: A review of its potential role in the prevention and treatment of postmenopausal osteoporosis. Hindawi Publishing Corporation. International Journal of endocrinology .2013; Article ID 316783.

Chasan PE. The history of injectable silicon fluids for soft-tissue augmentation. Plast Reconstr Surg. 2007; 120(7): 2034-40.

Eighteenth Report of the Joint FAO/WHO Expert Committee on Food Additives, Wld Hlth Org. techn. Rep. Ser., 1974, No. 557. FAO Nutrition Meetings Report Series,1974,No.54.

Teuber S, Yoshida S, Gershwin E. Immunopathologic effects of silicone breast implants. West J Med. 1995;162:418-25.

Narins RS, Beer K. Liquid injectable silicon : A review of its history, immunology, technical, consideration, complication, and potential. Plast. Reconstr. Surg. 2006; 118: Suppl.77S.

Elson ML. Injectable silicon for soft tissue augmentation. Cosmetic Dermatology. 2005; 18(11): 773-4.

Siqueira RC, Gil AD, Jorge R. Retinal detachment surgery silicon oil injection in transconjunctival sutureless 23-gauge vitrectomy. Arg Bras Oftalmol. 2007; 70(6): 905-9.

Prazeres J, Magalhaes Jr O, Lucatto LFA, Navarro RM, Moraes NS, et al. Heavy silicon oil as a long-therm endotamponade agent for complicated retinal detachments. BioMed Res Int. 2014;

Duan A, She H, Qi Y. Complications after heavy silicon oil tamponade in complicated retinal detachment. Retina. 2011; 31(3): 547-52.

Van Schie CH, Whalley A, Armstrong DG, Vileikyte L, Boulton AJ. Efficacy of injected liquid silicon in the diabetic foot to reduce risk factors for ulceration: A randomized double-blind placebo-controlled trial. Diabetes care. 2000; 23(5): 634-8.

Van Schie CH, Whalley A, Armstrong DG, Vileikyte L, Boulton AJ. The effect of silicon injections in the diabetic foot on peak plantar pressure and plantar tissue thickness: A 2-year follow-up. Arch Phys Med Rehabil. 2002; 83(7): 919-23.

Wallace WD, Balkin SW, Kaplan L, Nelson S. The histological host response to liquid silicon injections for prevention of pressure-related ulcers of the foot: A 38-year study. J Am Podiatric Med Assoc. 2004; 94(6): 550-7.

Gaber Y. Secondary lympoedema of the lower leg as an unusual side-effect of a liquid silicon injection in the hips and buttocks. Dermatology. 2004; 208(4): 342-4.

Merrill TJ, Mustafa ZC, Beverly M, Hernandez J. Silicon injection complications in the lower extremity: Migration, local reaction, and autoimmune response.

Ben-Hur N, Ballantyne DL Jr, Rees TD, Seidman I. Local and systemic effects of dimethylpolysiloxane fluid in mice. Plast Reconstr Surg. 1967; 39(4): 423-6.

C. T. Price, K. J. Koval, J. R. Langford. Review Article Silicon: A Review of Its Potential Role in the Prevention and Treatment of Postmenopausal Osteoporosis. Hindawi Publishing Corporation International Journal of Endocrinology. Vol 2013.

R. Jugdaohsingh. Silicon And Bone Health. J Nutr Health Aging. Europe PMC Funders Group. 2007; 11(2): 99-110.

D.T. Liles, F. Lin. Silicon Elastomeric Particles in Skin Care Applications. Science & Technology Department. 2010. Vol 1053. Chapter 11. Pp 207-219.

Nair A, Jacob S, Al-Dhublab B, Attimarad M, Harsha S. Basic considerations in the dermatokinetics of topical formulations. Brazilian Journal of Pharmaceuticals Sciences. 2013; 49(3): 423-34.




How to Cite

Harlim A, Aisah S, Sihombing R. Silicon level in skin tissues of normal female individuals. J Pak Assoc Dermatol [Internet]. 2018Dec.13 [cited 2024Jun.24];28(2):134-8. Available from:



Original Articles