Male androgenetic alopecia treated with finasteride

Authors

  • Naseema Kapadia
  • Tahir Jamil Ahmad
  • Tasneem Borhany

Keywords:

Androgenetic alopecia, finasteride

Abstract

Background Dihydrotestosterone causes micronization of scalp hair follicles, resulting in androgenetic alopecia. Finasteride inhibits type II 5α-reductase, thereby, decreasing the conversion of testosterone to dihydrotestosterone. Objective To determine the efficacy of finasteride in male androgenetic alopecia. Patients and methods 16 men from 18-42yrs of age with moderate vertex pattern hair loss received 1mg finasteride daily for 2 yrs. Efficacy was determined by patients self assessments, investigator assessment and assessment of clinical photographs. safety was assessed by clinical analysis of adverse experience if any Results After 6 months-1yr treatment, there was a significant improvement in patient, investigator and photographic assessment. Efficacy was improved and maintained throughout the second year of the study. Finasteride was generally well tolerated. Conclusion In men with male pattern hair loss finasteride 1mg for 2 yrs slowed the progression of hair fall and increased hair growth. 

References

Oslen EA. Androgenetic alopecia. In: Oslen EA, ed. Disorders of Hair Growth: Diagnosis and Treatment. New York: McGraw-Hill; 1994. p. 257-83.

Bergfeld WF. Androgenetic alopecia: an autosomal dominant disorder. Am J Med 1995; 98: 955-85.

Su LH, Chen THH. Association of androgenetic alopecia with smoking and its prevalence in Asian men. Arch Dermatol 2007; 143: 1401-6.

Hamilton JB. Male hormone stimulation is prerequisite in common baldness. Am J Anat 1942; 71: 451-80.

Kauffman K. Androgens metabolism at it affects hair growth in androgenetic alopecia. Dermatol Clin 1996; 14: 697-711.

Kauffman KD. Clinical studies on the effect of oral finasteride, a type II 5 alpha reductase inhibitor on scalp hair with male pattern baldness. In: Van Neste D, Randall VA, eds. Hair Research for the Next Millennium. Amsterdam: Elsevier Science; 1996. p. 363 -5.

Hamilton JB. Patterned hair loss in man: types and incidences: Ann NY Acad Sci 1951; 53: 708-14.

Norwood OTT. Male pattern baldness: Classification and incidence. South Med J 1975; 68: 1359-70.

Barber BL, Kauffman KD, Kozloff RC et al. A hair growth questionnaire for use in the evaluation of therapeutics effects in men. J Dermatol Treat 1998; 9: 181-6.

Neste DV, Fuh V, Sanchez-Pedreno P et al. Finesteride increases anagen hairs in men with androgenetic alopecia. Br J Dermatol 2001; 143: 804-10.

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Published

2016-12-24

How to Cite

1.
Kapadia N, Ahmad TJ, Borhany T. Male androgenetic alopecia treated with finasteride. J Pak Assoc Dermatol [Internet]. 2016Dec.24 [cited 2024Feb.26];18(4):232-4. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/601

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