A comparison of efficacy and safety of topical 0.1% adapalene and 4% benzoyl peroxide in the treatment of mild to moderate acne vulgaris
Keywords:
Acne vulgaris, benzoyl peroxide, adapalene, comedonesAbstract
Background Acne is an extremely common disease in the adolescent age group in Pakistan. Objectives To compare the efficacy and safety of topical 0.1% adapalene and 4% benzoyl peroxide in mild to moderate acne vulgaris. Patients and methods A total of 200 evaluable patients of more than 13 years of age with either sex were enrolled. One hundred patients were treated with topical 0.1% adapalene and 100 with 4% benzoyl peroxide for 12 weeks. Patients were followed up fortnightly. Results Both treatments were generally well tolerated leading to non-compliance in only 10 patients due to side effects. Efficacy was almost 80% in both groups. Conclusions Both treatments are equally effective and safe over 24 week period. Benzoyl peroxide is more effective in the treatment of inflammatory acne whereas adapalene is beneficial for the maintenance of comedonal acne.References
Simpson NB, Cunliffe WJ. Disorders of the pilosebaceous glands. In: Burns T, Cox N, Breathnach S, Christopher GC, eds. Rook’s Textbook Of Dermatology, 7th edn. London: Blackwell Publishing; 2004. P. 43.1-43.75.
Bergfeld WF. Topical retinoids in the management of acne vulgaris. J Drug Dev Clin Pract 1996; 8: 151-60.
Asad F, Qadir A, Ahmad L. Anxiety and depression in patients with acne vulgaris. J Pak Assoc Dermatol 2002; 12: 69-72.
Katsambas AD, Stefanaki C, Cunliffe WJ. Guidelines for treating acne. Clin Dermatol 2004; 22: 439-44.
Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol 2003; 49: 211-7.
Jain S. Topical tretinoin or adapalene in acne vulgaris. J Dermatol Treat 2004; 15: 200-7.
Weinberg JM. The utility of benzoyl peroxide in hydrophase base (Brevoxyl) in the treatment of acne vulgaris. J Drugs Dermatol 2006; 5: 344-9.
Dreno B, Ppli F. Epidemiology of Acne. Dermatology 2003; 20: 7-10.
11. Del Rosso JQ, Goodman M. Spotlight on treating inflammatory acne. Skin & Aging 2003; 11: 50-8.
Percy SH. Safety and efficacy of adapalene gel 0.1% in acne vulgaris: results of a post-marketing surveillance study. Indian J Dermatol Venereol Leprol 2003; 69: 277-80.
Thielitz A, Sidou F, Gollnick H. Control of microcomedone formation throughout a maintenance treatment with adapalene gel 0.1%. J Eur Acad Dermatol Venereol 2007; 21: 747-53.
Kanjee A, Rizwan S, Saeed S. Topical benzoyl peroxide 4% in the treatment of acne vulgaris. J Pak Assoc Dermatol 2001; 11: 20-4.
Rosso JQ. Pharmacotherapy Update: Highlights from the latest Acne treatment guidelines. Skin & Aging 2007; 15: 84-8.
Korkut C, Piskin S. Benzoyl peroxide, adapalene and their combination in the treatment of acne vulgaris. J Dermatol Treat 2005; 32: 169-73.
Stinco G, Bragadin G, Trotter D et al. Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. J Eur Acad Dermatol Venereol 2007; 21: 320-5.
do Nascimento LV, Guedes AC, Magalhães GM et al. Single-blind and comparative clinical study of the efficacy & safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% gel (QD) in the treatment of acne vulgaris for 11 weeks. J Dermatol Treat 2003; 14: 166-71.
Capizzi R, Landi F, Milani M, Amerio P. Skin tolerability & efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial. Br J Dermatol 2004; 151: 481-4.
Wolf JE, Loven KH, Rist T, Swinyer LJ. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin. J Am Acad Dermatol 2003; 49: S211-7.
Gollnick H, Cunliffe W. Management of acne: a report from a global alliance to improve outcomes in acne. J Am Acad Dermatol 2003; 49: S1-37.
Waller JM, Dreher F, Behnam S et al. 'Keratolytic' properties of benzoyl peroxide and retinoic acid resemble salicylic acid in man. Skin Pharmacol Physiol 2006; 19: 283-9.
Minciullo PL, Patafi M, Giannetto L et al. Allergic contact angioedema to benzoyl peroxide. J Clin Pharm Ther 2006; 31: 385-7.
Thiboutot DM, Weiss J, Bucko A et al. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind controlled study. J Am Acad Dermatol 2007; 57: 791-9.
