Comparison of Fractional CO2 Laser Versus Combined Platelet Rich Plasma and Fractional CO2 Laser in Treatment of Post Acne Scars

Abstract

Background: Acne scars are a common disfiguring sequelae of acne, significantly impacting patients' psychosocial well-being. A comprehensive approach tailored to individual needs is essential to treat this complex condition. Fractional carbon dioxide laser induces controlled injury to the skin promoting scar remodeling. PRP is rich in growth factors and cytokines that accelerate wound healing. Combining the two modalities may yield synergistic benefits. Objective: To compare the results of fractional CO2 laser treatment versus a combination of platelet-rich plasma and fractional CO2 laser treatment for post-acne scars. Methods: This randomized control trial was conducted at Department of Dermatology, Mayo Hospital, Lahore from 16-08-2021 to 15 -02-2022. A total of 178 patients were enrolled and divided into 2 groups, group-A and group-B. Group-A was treated with fractional CO2 laser alone while group-B patients were treated using fractional CO2 laser followed by intradermal platelet rich plasma (PRP) injection. The outcome of patients was compared in terms of Goodman and Baron's acne scar grading scale at baseline and 3 months follow up. Data was analyzed statistically and was expressed as mean ± SD or frequency (%). Results: The mean 3 months post-treatment Goodman and Baron's score of group B (2.15 ± 0.66) was significantly reduced than that of group A (2.43 ± 0.65) with p-value= 0.04. Conclusion: Our study demonstrated that fractional CO2 laser treatment combined with PRP showed more favorable results in treatment of post-acne scars at 3 months compared to fractional CO2 alone.