HCV seropositivity in patients with lichen planus

Authors

  • Farzana Faiz Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore
  • Najam Us Saher Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore
  • Sara Innayat Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore
  • Umara Siddique Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore
  • Khawar Khurshid Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore

Keywords:

Lichen planus, hepatitis C, ELISA

Abstract

Objectives To determine the frequency of HCV seropositivity in patients diagnosed with lichen planus (LP). Methods This cross-sectional study was conducted in the Department of Dermatology Unit-II, Mayo Hospital, and Lahore. Sera of 100 patients of LP diagnosed clinically and by histopathology in doubtful cases were assessed for HCV seropositivity. The patients were screened for the presence of anti-HCV antibodies by second generation ELISA. Results 14% of LP patients showed anti-HCV antibodies. Among these, 9 (9%) were females while 5 (5%) were males. Ages of the patients ranged from 3 to 70 years. Majority (64%) of the patients seropositive for HCV were 16 to 45 years of age. Conclusion All patients of LP should be screened for HCV seropositivity to detect undiagnosed cases of hepatitis C virus.

Author Biographies

Farzana Faiz, Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore

Department of Dermatology, Unit II

Najam Us Saher, Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore

Department of Dermatology, Unit II

Sara Innayat, Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore

Department of Dermatology, Unit II

Umara Siddique, Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore

Department of Dermatology, Unit II

Khawar Khurshid, Department of Dermatology, Unit II, King Edward Medical University/Mayo Hospital, Lahore

Department of Dermatology, Unit II

References

Pittelkow MR, Daoud MS. Lichen Planus. In: Wolff K, Goldsmith LA, Katz SI, editors. Fitzpatrick's Dermatology in General Medicine, 7th ed. New York: McGraw-Hill; 2008. P. 244-48.

Prabhu S, Pavithran K, Sobhanadevi G. Lichen planus and hepatitis c virus (HCV)-Is there an association? A serological study of 65 cases. Indian J Dermatol Venereol Leprol. 2002;68:273.

Sánchez‐Pérez J, Castro M, Buezo GF, Herrera JF, Borque MJ, García‐Diez A. Lichen planus and hepatitis C virus: prevalence and clinical presentation of patients with lichen planus and hepatitis C virus infection. Br J Dermatol. 1996;134:715-9.

Rabiei M, Mohtasham AZ. Prevalence of lichen planus in HCV infected patients of Gilan province (Iran), 2002. J Thro Haem. 2007;5:903.

Amer MA, El‐Harras M, Attwa E, Raslan S. Lichen planus and hepatitis C virus prevalence and clinical presentation in Egypt. J Eur Acad Dermatol Venereol. 2007;21:1259-60.

Mahboobi N, Agha-Hosseini F, Lankarani KB. Hepatitis C virus and lichen planus: the real association. Hepatitis Monthly. 2010;10:161.

Udayashankar C, Nath A, DSouza M. Hepatitis C Virus serology in patients with lichen planus. Internet J Dermatol. 2009;7(2):23.

Samdani AJ. Association of lichen planus with hepatitis C virus infection. Ann Saudi Med. 2005;25:243-6.

Sánchez‐Pérez J, Castro M, Buezo GF, Herrera JF, Borque MJ, García‐Diez A. Lichen planus and hepatitis C virus: prevalence and clinical presentation of patients with lichen planus and hepatitis C virus infection. Br J Dermatol. 1996;134:715-9.

Guerreiro TD, Machado MM, Freitas TH. Association between lichen planus and Hepatitis C virus infection: a prospective study with 66 patients of the dermatology department of the hospital Santa Casa de Misericórdia de São Paulo. An Bras de Dermatol. 2005;80:475-80.

Frank C, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet. 2000;355:887-91.

Touzet S, Kraemer L, Colin C, Pradat P, Lanoir D, Bailly F et al. Epidemiology of hepatitis C virus infection in seven European Union countries: a critical analysis of the literature. Eur J Gastroenterol Hepatol. 2000;12:667-78.

Meij EV, Waal IV. Hepatitis C virus infection and oral lichen planus: a report from the Netherlands. J Oral Pathol Med. 2000;29:255-8.

Carrozzo M, Gandolfo S. Oral diseases possibly associated with hepatitis C virus. Crit Rev Oral Biol Med. 2003;14:115-27.

Das A, Das J, Majumdar G, Bhattacharya N, Neogi DK, Saha B. No association between seropositivity for hepatitis C virus and lichen planus: a case control study. Indian J Dermatol Venereol Leprol. 2006;72:198.

Mogaddam MR, Anamzade F. Survey of relationship between hepatitis C and lichen planus among dermatology outpatients of Imam Hospital of Ardabil city. J Pak Assoc Dermatol. 2010;20:19-22.

Downloads

Published

2017-03-29

How to Cite

1.
Faiz F, Saher NU, Innayat S, Siddique U, Khurshid K. HCV seropositivity in patients with lichen planus. J Pak Assoc Dermatol [Internet]. 2017Mar.29 [cited 2025Jan.23];26(3):240-3. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/29

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 3 > >>