Global trends and Publication on Secretome in Dermatology Practice: A Bibliometrics Analysis from 2003 to 2023
Keywords:
Secretome, dermatology, Publication trend, bibliometrics, research topicsAbstract
Background: The secretome, also known as conditioned medium, is a collection of proteins and other molecules secreted by Mesenchymal stem cells (MSCs), has been increasingly studied for its potential applications in dermatology practice. However, there has been limited bibliometric analysis to understand the global trends in this field. Objective: To analyze the global trends and publication activity related to secretome in dermatology practice through bibliometrics analysis. Method: A systematic search was performed using the Web of Science Core Collection database to identify relevant publications on secretome in dermatology practice from 2003 to 2023. Statistical analyses were performed using Excel and VOSviewer software. Various bibliometric indicators were analyzed to evaluate the publication trends, research topics, and collaboration networks. Result: A total of 304 articles with H-index 45 and 20,74 citations per paper related to secretome in dermatology practice were identified. The annual publication output showed an upward trend, with a peak in 2022. The United States (57) had the highest number of publications, followed by China (37) and Germany (37). The most common research topics were wound healing, skin regenerative & rejuvenation, inflammatory skin diseases, skin cancer and hair growth. For promising hotspots, “exosomes and regenerative medicine” showed the highest, followed by “senescence”, “photoaging”, and “wound repair” Conclusion: Our bibliometric analysis demonstrates that secretome research in dermatology practice has been an increasingly studied field with potential applications in the development of novel therapeutics for skin disorders. Collaboration among researchers and countries is crucial for advancing secretome research in dermatology practice.References
Robert AW, Azevedo Gomes F, Rode MP, et al. The skin regeneration potential of a pro-angiogenic secretome from human skin-derived multipotent stromal cells. J Tissue Eng. 2019;10:2041731419833391. doi: 10.1177/2041731419833391
Walter MN, Wright KT, Fuller HR, MacNeil S, Johnson WEB. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res. 2010;316(7):1271–1281.
Miranda JP, Filipe E, Fernandes AS, et al. The human umbilical cord tissue-derived MSC population UCX®promotes early motogenic effects on keratinocytes and fibroblasts and G-CSF-mediated mobilization of BM-MSCs when transplanted in vivo. Cell Transplant. 2015;24(5):865–877. -0785-5
Bhang SH, Lee S, Shin J-Y, Lee T-J, Jang H-K, Kim B-S. Efficacious and clinically relevant conditioned medium of human adipose-derived stem cells for therapeutic angiogenesis. Mol Therapy. 2014;22(4):862–872.
Sagaradze G, Grigorieva O, Nimiritsky P, et al. Conditioned medium from human mesenchymal stromal cells: towards the clinical translation. Int J Mol Sci. 2019;20(7):1656
Park S-R, Kim J-W, Jun H-S, Roh JY, Lee H-Y, Hong I-S. Stem cell secretome and its effect on cellular mechanisms relevant to wound healing. Mol Therapy. 2018;26(2):606–617. doi: 10.1016/j.ymthe.2017.09.023
Balasubramanian S, Thej C, Walvekar A, et al. Evaluation of the secretome profile and functional characteristics of human bone marrow mesenchymal stromal cells-derived conditioned medium suggest potential for skin rejuvenation. J Cosmetics Dermatol Sci Applications. 2017;7(01):99.
Niada S, Giannasi C, Magagnotti C, Andolfo A, Brini AT. Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts. J Proteomics. 2021;232:104069
Collawn SS, Mobley JA, Banerjee NS, Chow LT. Conditioned media from adipose-derived stromal cells accelerates healing in 3-dimensional skin cultures. Ann Plast Surg. 2016;76(4):446–452.
Zhao J, Yu G, Cai M, Lei X, Yang Y, Wang Q, et al. Bibliometric analysis of global scientific activity on umbilical cord mesenchymal stem cells: a swiftly expanding and shifting focus. Stem Cell Res Ther [Internet]. 2018 Dec [cited 2023 Jul 25];9(1):32. Available from: https://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0785-5
Manriquez J, Andino-Navarrete R, Cataldo-Cerda K, Harz-Fresno I. Bibliometric characteristics of systematic reviews in dermatology: A cross-sectional study through Web of Science and Scopus. Dermatologica Sinica [Internet]. 2015 Sep [cited 2023 Jul 25];33(3):154–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1027811714000883
Seivright JR, Cheng MY, Villa NM, Shi VY, Hsiao JL. Bibliometric analysis of original research in four high‐impact dermatology journals. Int J Dermatol [Internet]. 2021 Aug [cited 2023 Jul 25];60(8). Available from: https://onlinelibrary.wiley.com/doi/10.1111/ijd.15401
Liu Z jiang, Wang M juan, Luo J, Tan Y ting, Hou M, Wang S chao. A bibliometric analysis of hotpots and trends for the relationship between skin inflammation and regeneration. Front Surg [Internet]. 2023 Apr 21 [cited 2023 Jul 25];10:1180624. Available from: https://www.frontiersin.org/articles/10.3389/fsurg.2023.1180624/full
