The association between vulvovaginal candidiasis and hormonal contraceptive use in the outpatient clinic of Dr Soetomo Hospital, Surabaya in 2017-2020: A retrospective study
Keywords:
hormonal contraceptives, sexually transmitted infection, vulvovaginal candidiasisAbstract
Background Vulvovaginal candidiasis (VVC) is one of the most common sexually transmitted infection (STI). With the increasing use of hormonal contraceptives, it is becoming increasingly important to investigate the role of hormonal contraceptives on the occurrence of VVC. This study aims to explore the association between hormonal contraceptive use and VVC. Â Methods This retrospective unmatched case-control study enrolled patients from the STI outpatient clinic of the the Dr. Soetomo Regional General Hospital Surabaya in 2017-2020. Â Results A total of 308 patients presented to the clinic, 132 (42.9%) of whom had VVC, and 84 (27.3%) of whom used hormonal contraceptives. Hormonal contraceptive use may increase the odds of developing VVC by 3.4-folds (95% CI: 1.97-5.89; p<0.001), independent of STI history and immunodeficiency disorders. In addition, oral contraceptive pills may increase the odds by 2.3-folds (95% CI: 1.25-4.34; p=0.008), while other hormonal contraceptives such as injectable or implants may increase the odds by 8.7-folds (95% CI: 3.13-24.28; p<0.001). Patients using hormonal contraceptives had a probability of suffering from VVC of 58.8%, while those of patients using OCPs and other hormonal contraceptives were 49.5% and 78.6%, respectively. Â Conclusion This study proves that hormonal contraceptives is a risk factor to the occurrence of VVC. ÂReferences
Tasik NL, Kapantow GM, Kandou RT. Profil Kandidiasis Vulvovaginalis di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari – Desember 2013. Manado: Fakultas Kedokteran, Universitas Sam Ratulangi., (no date).
Denning, D.W., Kneale, M., Sobel, J.D., Rautemaa-Richardson, R., (2018). 'Global burden of recurrent vulvovaginal candidiasis: a systematic review'. Lancet Infect. Dis. 18, e339–e347. https://doi.org/10.1016/S1473-3099(18)30103-8
https://doi.org/10.2105/AJPH.2015.302839
InfoDATIN Pusat Data dan Informasi Kementrian Kesehatan RI, (2013). 'Situasi dan Analisis Keluarga Berencana'. Kementrian Kesehat. Repub. Indones.
Jasim, S.T., (2020). 'The relationship between vulvovaginal candidiasis and some predisposing factors in prevalence among Baghdad women'. Syst. Rev. Pharm. 11.
Salih, S., Haddad, R., Hassan, S., (2021). 'Prevalence of vulvovaginal Candidiasis and its association with Contraceptives'. Arch. Venez. Farmacol. Ter. 40, 373–376. https://doi.org/10.5281/zenodo.5224567
Fayemiwo, S.A., Makanjuola, O.B., Fatiregun, A.A., (2017). 'Vulvo-vaginal candidosis in a cohort of hormonal contraceptive users in Ibadan, Nigeria'. Afr. J. Clin. Exp. Microbiol. 19, 38. https://doi.org/10.4314/ajcem.v19i1.6
Jessica, P., Armalina, D., (2016). 'Hubungan antara terjadinya kandidiasis vulvovaginalis dengan penggunaan kontrasepsi hormonal'. J. Kedokt. Diponegoro 5.
Armerinayanti, N., Lestari, D., (2018). 'Risiko Kandidiasis pada Wanita Usia Subur Akseptor Kontrasepsi Hormonal'. WMJ Warmadewa Med. J. 3, 22. https://doi.org/10.22225/wmj.3.1.640.22-27
Jacob, L., John, M., Kalder, M., Kostev, K., (2018). 'Prevalence of vulvovaginal candidiasis in gynecological practices in Germany: A retrospective study of 954,186 patients'. Curr. Med. Mycol. 4, 6–11. https://doi.org/10.18502/cmm.4.1.27
Jalalvandi, E., Jafari, H., Amorim, C.A., Petri, D.F.S., Nie, L., Shavandi, A., (2021). 'Vaginal administration of contraceptives'. Sci. Pharm. 89, 3. https://doi.org/10.3390/scipharm89010003
Arfiputri, D.S., Hidayati, A.N., Handayani, S., Ervianti, E., (2018). 'Risk factors of vulvovaginal candidiasis in dermato-venereology outpatients clinic of soetomo general hospital, Surabaya, Indonesia'. Afr. J. Infect. Dis. 12, 90–94. https://doi.org/10.2101/Ajid.12v1S.13
Sovianti, C.S., Devi, M., (2021). 'Recurrent vulvovaginal candidiasis'. Biosci. Med. J. Biomed. Transl. Res. 5, 474–483. https://doi.org/10.32539/bsm.v5i5.280
Ekpenyong, C.E., Inyang-etoh, E.C., Ettebong, E.O., Akpan, U.P., Ibu, J.O., Daniel, N.E., (2012). 'Recurrent vulvovaginal candidosis among young women in south eastern Nigeria: the role of lifestyle and health-care practices'. Int. J. STD AIDS 23, 704–709. https://doi.org/10.1258/ijsa.2012.011382
Bitew, A., Abebaw, Y., (2018). 'Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern'. BMC Womens Health 18, 94. https://doi.org/10.1186/s12905-018-0607-z
Brocklebank, A., Maraj, H., (2013). 'Vulvovaginal candidiasis'. InnovAiT Educ. Inspir. Gen. Pract. 6, 643–651. https://doi.org/10.1177/1755738013479944
Rathod, S.D., Klausner, J.D., Krupp, K., Reingold, A.L., Madhivanan, P., (2012). 'Epidemiologic features of vulvovaginal candidiasis among reproductive-age women in India'. Infect. Dis. Obstet. Gynecol. 2012, 859071. https://doi.org/10.1155/2012/859071
Sawada, T., Fujimori, D., Yamamoto, Y., (2019). 'Systemic lupus erythematosus and immunodeficiency'. Immunol. Med. 42, 1–9. https://doi.org/10.1080/25785826.2019.1628466
Sherwood, L., (2016). 'Human Physiology: From Cells to Systems, 9th Ed. ed'. Cengage Learning, Canada.
