Frequency of anti-HCV antibodies in lichen planus patients attending a tertiary care hospital Quetta, Balochistan
Keywords:
Anti HCV antibodies, Lichen planus, Lichen planopilaris, Hepatitis C, Quetta Extrahepatic manifestions, Oral LPAbstract
Background Lichen planus (LP) is a common inflammatory disorder of the skin and mucous membranes having an unknown etiology. In addition to skin and mucous membranes, it also involves nails and hair. Classically it is characterized by pruritic, purple, polygonal, plan-topped papules and may have different clinical presentations like erosive, hypertrophic, atrophic, follicular (Lichen planopilaris), linear, actinic, pigmentosus, annular, guttate, and vesiculobullous. In recent years, many research articles showed association of Lichen planus with HCV infection. So, it is important to establish the clinical role of Lichen planus in the diagnosing of hepatitis C virus is an a pivotal and practical task. Methods This is a cross sectional study, having consecutive sampling of Non probability type. It is conducted at department of dermatology, Sandeman (Provincial) Hospital/ Bolan Medical College Quetta between January 2018 to June 2018. All the patients of either gender, aged 30 to 60 years and clinically diagnosed with Lichen Planus were enrolled. After a complete history and clinical examination, anti HCV antibodies was checked by kit method in the institutional laboratory. Results The mean age was 46.42 ±9.75 years. There were 89 (53.9%) females while 76 (46.1%) males. Mean duration of symptoms was 3.20±1.16 weeks. Frequency of positive anti HCV antibody was found in 53 (32.1%) patients while 112 (67.9%) patients were found to be negative. Conclusion The results of high frequency of Anti HCV antibodies support a possible association with lichen planus.References
Stark S K, Al-Hamdi K I, Alabood M H. A study of lichen planus and its association with hepatitis C infection. J Taibah Univ Med Sci. 2015;10(2):222-6.
Le Cleach L, Chosidow O. Clinical practice. Lichen planus. N Engl J Med. 2012;366(8):723-32.
Petti S, Rabiei M, De Luca M, et al. The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study. Odontology. 2011;7(2):168-78.
Shrestha R, Shrestha S. Clinico-epidemiological study of Lichen Planus and its association with Hepatitis C. JGPEMN. 2014;3(1):37-41.
Omal P M, Jacob V, Prathap A, et al. Prevalence of Oral, Skin, and Oral and Skin Lesions of Lichen Planus in Patients Visiting a Dental School in Southern India.Indian J Dermatol. 2012;3(2):107–109.
Anwar S, Khalid M, Shaheen J A. Frequency of cutaneous manifestations inpatients of hepatitis C infection. J Pak AssocDermatol. 2015;25(4):285-90.
Rahman A, Rizvi S D A, Sheikh Z I. frequency of HCV infection in different dermatological disorders. J Ayub Med Coll Abbottabad. 2012;24(2):58-61.
Ali R, Ashfaq M, Bukhari M A, et al. Mucocutaneous manifestations in hepatitis C patients. J Pak Assoc Dermatol. 2014;24(1):40-45.
Qazi J A, Qazi A H. The association between oral Lichen Planus and HCV Infection. J Dow Uni Health Sci. 2011;5(1)3-5.
Mahboob A, Haroon TS, Iqbal Z, et al. Frequency of anti-HCV antibodies in patients with lichen planus. J Coll Phys Surg Pak. 2003;13(5):248-51
