Psoriatic patients are associated with increased risk of developing metabolic syndrome: An institution based case control study
Psoriasis and metabolic syndrome
Keywords:
Psoriasis, Metabolic syndrome, PASI scoreAbstract
Abstract: Introduction: Psoriasis is a chronic inflammatory cutaneous disorder with significant impairment in the quality of life. Already published data also suggest that psoriasis patients are prone to develop different cardiological and psychological comorbidities. Aims and Objectives: This study aimed to find out the association of metabolic syndrome, risk factors, individual components of metabolic syndrome and the other related parameters in patients with psoriasis and compare it with non-psoriatic patients. Materials & Methods: Institution based case control study including 101 patients of psoriasis & 90 controls. Data analysis statistically done by using t-test/ ANOVA test or chi square/ Fischer’s test. Result: In this study, we found strong correlation between types of psoriasis (plaque type 76.47% followed by erythrodermic type 14.71% of psoriatic patients with metabolic syndrome) and metabolic syndrome while no such association found with severity of psoriasis (PASI score) , different demographic parameters with metabolic syndrome in both the groups. At the same time smoking and alcohol consumption were found to be significant risk factors for developing metabolic syndrome. Conclusion: In our study, there is a significantly higher prevalence of metabolic syndrome in patients with psoriasis comparing to non psoriatic population while it failed to show any significant association between psoriasis and dyslipidemia.References
Schon MP, Boehncke WH. Psoriasis. N Engl J Med 2005;352:1899-912.
Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: A population-based study. Arch Dermatol 2005;141:1537-41.
Dogra S, Yadav S. Psoriasis in India: Prevalence and pattern. Indian J Dermatol Venereol Leprol 2010;76:595-601.
Lima Ede A, Lima Mde A. Reviewing concepts in the immunopathogenesis of psoriasis. An Bras Dermatol. 2011;86:1151-8.
Reich K. The concept of psoriasis as a systemic inflammation: implications for disease management. J Eur Acad Dermatol Venereol. 2012;26:3-11.
Henseler T, Christophers E. Disease concomitance in psoriasis. Journal of the American Academy of Dermatology. 1995;32:982–986.
Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M. Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 2006;298(7):321–8.
Takahashi H, Iizuka H. Psoriasis and metabolic syndrome. J Dermatol. 2012;39:212-8.
Vettor R, Milan G, Rossato M, Federspil G. Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 2005;22:3–10. 99
Correia ML, Rahmouni K. Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes Obes Metab 2006;8:603–10.
Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K et al. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 2004;43:1318–23.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Ecke RH, Franklin BA et al. Diagnosis and Management of the Metabolic Syndrome. Circulation 2005;112:2735-52.
Eckel RH. The Metabolic Syndrome. In: Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo, editors. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012. p.1992-7.
Expert panel on detection,evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
Parikh RM, Mohan V. Changing definitions of metabolic syndrome. Indian J Endocr Metab 2012;16:7-12.
Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol 2010;76:662-5.
Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study. Br J Dermatol 2007;157:68-73
Kim GW, Park HJ, Kim HS, Kim SH, Ko HC, Kim BS et al. Analysis of cardiovascular risk factors and metabolic syndrome in korean patients with psoriasis. Ann Dermatol 2012;24:11-5.
Zindancı I, Albayrak O, Kavala M, Kocaturk E, Can B, Sudogan S et al. Prevalence of metabolic syndrome in patients with psoriasis. ScientificWorldJournal 2012;2012:312463.
Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study. Indian J Dermatol 2012;57:353-7
Chen YJ, Wu CY, Shen JL, Chu SY, Chen CK, Chang YT et al. Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome. Arch Dermatol 2008;144:1571-5.
Pereira RR, Amladi ST, Varthakavi PK. A study of the prevalence of diabetes, insulin resistance, lipid abnormalities, and cardiovascular risk factors in patients with chronic plaque psoriasis. Indian J Dermatol 2011;56:520-6.
Herron MD, Hinckley M, Hoffman MS, Papenfuss J, Hansen CB, Callis KP et al. Impact of obesity and smoking on psoriasis presentation and management. Arch Dermatol 2005;141:1527-34.
