Frequency of dyslipidemia in patients with psoriasis
Keywords:
Psoriasis, dyslipidemiaAbstract
Objective To determine the frequency of dyslipidaemia in psoriatic patients. Methods A cross-sectional study was carried out in the Department of Dermatology, Jinnah hospital, Lahore for the duration of six months. A total of 120 patients suffering from psoriasis, of any severity, belonging to either sex and with age between 15-70 years were included in the study. All patients in the study were investigated for total cholesterol, triglycerides, low-density lipoproteins and high-density lipoproteins after 12-14 hours of overnight fasting. Results The mean age of the patients was 38.59 ± 13.86 years. There were 78 (65%) male and 42 (35%) female patients. The mean duration of psoriasis was 5.46 ± 4.49 years. The mean PASI score was 14.98 ± 8.95. There were 67 (55.8%) patients having dyslipidaemia and 53 (44.2%) patients had normal lipid levels. 34 (28.3%) patients had raised total cholesterol (>200mg/dl), 32 (26.7%) raised low-density lipoprotein-cholesterol (>130 mg/dl), 44 (36.7%) hypertriglyceridemia (>150mg/dl) and 35 (29.2%) patients had reduced high-density lipoprotein-cholesterol levels (<40mg/dl). Conclusion It is concluded from this study that patients of psoriasis have a high incidence of dyslipidaemia, as it was found in 55.8% of psoriatic patients.  ÂReferences
Myers WA, Gottlieb AB, Mease P. Psoriasis and psoriatic arthritis: clinical features and disease mechanisms. Clin Dermatol. 2006;24:438-47.
Gelfand JM, Stern RS, Nijsten T et al. The prevalence of psoriasis in African Americans: results from a population- based study. J Am Acad Dermatol. 2005;52:23-6.
Gudjonsson JE, Elder JT. Psoriasis. Fitzpatrick’s Dermatology In General Medicine, 7th ed. New York: McGraw-Hill; 2008. P. 169-93.
Bajaj DR, Mahesar SM, Devrajani BR, Iqbal MP. Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad. J Pak Assoc Dermatol. 2009;59:512-5.
Akhyani M, Ehsani AH, Robati RM, Robati AM. The lipid profile in psoriasis: a controlled study. J Eur Acad Dermatol Venereol. 2007;21:1330-2.
Dreiher J, Weitzman D, Davidovici B et al. Psoriasis and dyslipidaemia: A population-based study. Acta Derm Venereol. 2008;88:561-5.
Cohen AD, Gilutz H, Henkin Y et al. Psoriasis and the metabolic syndrome. Acta Derm Venereol. 2007;87:506-9.
Cohen AD, Sherf M, Vidavsky L et al. Association between psoriasis and the metabolic syndrome. A cross-sectional study. Dermatology. 2008;216:152-5.
Brauchli YB, Jick SS, Meier CR. Psoriasis and the risk of incident diabetes mellitus: a population-based study. Br J Dermatol. 2008;159:1331-7.
Späh F. Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. Br J Dermatol. 2008;159 (suppl 2):10-7.
Brauchli YB, Jick SS, Miret M, Meier CR. Psoriasis and the risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case-control analysis. Br J Dermatol. 2009;160:1048-56.
Prodanovich S, Kirsner RS, Kravetz JD et al. Association of psoriasis with coronary artery, cerebrovascular and peripheral vascular diseases and mortality. Arch Dermatol. 2009;145:700-3.
Escarcega RO, Garcia-Carrasco M, Fuentes-Alexandro S et al. Insulin resistance, chronic inflammatory state and the link with systemic lupus erythematosus-related coronary disease. Autoimmun Rev. 2006;6:48-53.
Aprahamian T, Rifkin I, Bonegio R et al. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004;199:1121-31.
Neimann AL, Shin DB, Wang X et al. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829-35.
Farshchian M, Zamanian A, Farshchian M et al. Serum lipid level in Iranian patients with psoriasis. J Eur Acad Dermatol Venereol. 2007;21:802-5.
Javidi Z, Meibodi NT, Nahidi Y. Serum lipids abnormalities and psoriasis. Indian J Dermatol. 2007;52:89-92.
Piskin S, Gurkok F, Ekuklu G, Senol M. Serum lipid levels in psoriasis. Yonsei Med J. 2003;44:24-6.
Mallbris L, Granath F, Hamsten A, Stahl M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol. 2006;54:614-21.
Tekin NS, Tekin IO, Barut F, Sipahi EY. Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients. Mediators Inflamm. 2007;2007:78454
Iqbal SP, Dodani S, Qureshi R. Risk factors and behaviors for coronary artery disease (CAD) among ambulatory Pakistanis. J Pak Med Assoc. 2004;54:261-6.