Clinical features, laboratory data and prognosis in patients with erythroderma admitted in dermatology ward

Authors

  • Maryam Khalili Assistant professor of dermatology, Department of Dermatology, Kerman University of Medical Sciences, Iran
  • Saeedeh Habibipour General Practitioner, Kerman University of Medical Sciences, Iran
  • Rezvan Amiri Assistant professor of dermatology, Department of Dermatology, Kerman University of Medical Sciences, Iran
  • Mahin Aflatoonian Associate professor of dermatology, Clinical Research Development Unite, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

Keywords:

Erythroderma, Clinical, Prognosis

Abstract

Background Erythroderma or exfoliative dermatitis is characterized with generalized erythema of the skin, involving approximately 90% of the body surface area. In this study, we determine prevalence of different types of erythroderma as well as clinical and laboratory features in patients admitted in dermatology ward of Afzalipour hospital, Kerman.   Methods  This is a retrospective cross-sectional study on patients with erythroderma during ten-year period (2010-2019). Correlation of underlying disease with demographics and clinical features of the patients was evaluated by independent t test and chi-square test.   Results  Prevalence of erythroderma was 12.1%. Most of the patients were in their fourth or sixth decades of life. Drug eruption, autoimmune bullous diseases and cutaneous T cell lymphoma (CTCL) were observed most commonly in females (P=0.001). The shortest and longest duration belonged to drug eruption and CTCL, respectively (P=0.001). The most common clinical symptoms and signs were pruritus (91.5%), lymphadenopathy (20.9%) and fever (20.3). The most frequent laboratory abnormality was elevated liver enzymes (83.05%).The most common causes of erythroderma were exacerbation of pre-existing dermatoses (54.2%), drug eruption (35.6%) and idiopathic (7.3%). The most prevalent causes of pre-existing skin diseases were psoriasis (35%), dermatitis (13%) and lichen planus (2.3%).   Conclusion The most common causes of erythroderma were exacerbation of pre-existing dermatoses (mainly psoriasis and dermatitis), drug eruption and idiopathic. The most common causes of acute and chronic erythroderma were drug eruption and psoriasis, respectively. The most frequent clinical (other than erythema and scaling) and laboratory findings were pruritus and elevated liver enzymes, respectively.  

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Published

2023-07-02

How to Cite

1.
Khalili M, Habibipour S, Amiri R, Aflatoonian M. Clinical features, laboratory data and prognosis in patients with erythroderma admitted in dermatology ward. J Pak Assoc Dermatol [Internet]. 2023Jul.2 [cited 2025Feb.8];33(2):593-8. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/2177

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