COMPARISON OF EFFICACY OF TOPICAL TAZAROTENE WITH TOPICAL ADAPALENE IN THE TREATMENT OF FACIAL ACNE VULGARIS

Authors

  • farah sagheer Dermatology Department Lady Reading Hospital medical teaching institute Peshawar Pakistan
  • Mohammad majid paracha Dermatology Department Lady Reading Hospital medical teaching institute Peshawar Pakistan
  • sassi jokhio Dermatology Department Lady Reading Hospital medical teaching institute Peshawar Pakistan
  • Sadia Naseem Dermatology Department Lady Reading Hospital medical teaching institute Peshawar Pakistan

Abstract

INTRODUCTION: Acne is a chronic inflammatory disease of pilosebaceous units. It is characterized by seborrhea, formation of comedones, erythematous papules and pustules less frequently by nodules, deep pustules or pseudocysts and in some cases accompanied by scaring.1 Types of acne include acne vulgaris, acne fulminans, acne conglobata, occupational acne, prepubertal acne. Acne vulgaris is among the most common skin diseases in adolescents and adults; affecting more than 85 % of adolescents.2 This study will give us local statistics of efficacy of topical adapalene and topical tazarotene in the treatment of facial acne vulgaris and the results of this study will be used as evidence for future research and treatment recommendations for facial acne vulgaris. OBJECTIVE: To compare the efficacy of topical tazarotene with topical adapalene in the treatment of facial acne vulgaris. METHODS: In this study 44 patients in each group were allocated by lottery method. Patients in group A were subjected to topical tazarotene gel (0.1%) three times a day for 4 weeks (amount pea size) while patients in group B were subjected topical adapalene gel (0.1%) three times a day for 4 weeks (amount pea size). All patients were followed at the end of 4 weeks after start of therapy. Treatment was considered effective if there is at least 50% reduction in number of lesions from baseline. RESULTS: mean age in Tazarotene Gel Group (A) was 28 years ± 12.15 while mean age in Topical Adapalene Gel Group (B) was 26 years SD ± 11.84. In Tazarotene Gel Group (A) 18(41%) patients were male and 26(59%) patients were female. In Topical Adapalene Gel Group (B) 17(39%) patients were male and 27(61%) patients were female. Efficacy among two groups was analyzed as Tazarotene Gel Group (A) was effective in 29(66%) patients while Topical Adapalene Gel Group (B) was effective in 27(61%) patients.  CONCLUSION: Our study concludes that topical Tazarotene gel was found to be more effective then topical Adapalene (66% vs 61%) in the treatment of facial acne vulgaris

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Published

2022-08-27

How to Cite

1.
sagheer farah, majid paracha M, jokhio sassi, Naseem S. COMPARISON OF EFFICACY OF TOPICAL TAZAROTENE WITH TOPICAL ADAPALENE IN THE TREATMENT OF FACIAL ACNE VULGARIS. J Pak Assoc Dermatol [Internet]. 2022Aug.27 [cited 2024Jul.13];32(3):539-44. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1929

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