The Role of Skin and Gut Microbiome in Atopic Dermatitis

Authors

  • Menul Ayu Umborowati, MD Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo Teaching Hospital, Surabaya, Indonesia. | Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Indonesia.
  • Nurdini Wilda Salsabila, MD Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo Teaching Hospital, Surabaya, Indonesia
  • Damayanti, MD, PhD Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo Teaching Hospital, Surabaya, Indonesia
  • Sylvia Anggraeni, MD Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo Teaching Hospital, Surabaya, Indonesia. | Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Indonesia.
  • Prof. Cita Rosita Sigit Prakoeswa, MD, PhD Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo Teaching Hospital, Surabaya, Indonesia

Abstract

In the last decade, there has been an increase in atopic dermatitis (AD) worldwide. AD is a chronic inflammatory skin disease characterized by mild to severe itching, recurrent, and mostly occurred in infancy and childhood. There were some substantial data of patients with AD that have been disturbed and less diverse skin and gut microbes than healthy individuals. AD is known to possess a higher proportion of Staphylococcus aureus (S. aureus) in the skin microbiome than healthy individuals. In addition, the population of Clostridium difficile, Escherichia coli, and Staphylococcus aureus in the gastrointestinal tract of patients with AD is higher than normal individuals, whereas the population of Bifidobacteria, Bacteroidetes, and Bacteroides are experienced a decrease. The AD will be prevented or treated if there is a balance in the gut and skin microbiome. It seems to underlie the benefit of probiotic in AD management.

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Published

2022-03-29

How to Cite

1.
Menul Ayu Umborowati, MD, Nurdini Wilda Salsabila, MD, Damayanti, MD, PhD, Sylvia Anggraeni, MD, Prof. Cita Rosita Sigit Prakoeswa, MD, PhD. The Role of Skin and Gut Microbiome in Atopic Dermatitis. J Pak Assoc Dermatol [Internet]. 2022Mar.29 [cited 2024Dec.2];32(1):148-55. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1816

Issue

Vol. 32 No. 1 (2022): January - March

Section

Review Articles

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