Chronic spontaneous urticaria in autoimmune connective tissue diseases


  • Yahya Argobi


Objective Chronic spontaneous urticaria is one of the most troubling symptoms in autoimmune connective tissue diseases (ACTDs). Our aim is to better characterize the association between chronic spontaneous urticaria and ACTDs.  Methods A retrospective study of patients seen at ACTDs clinic at Massachusetts General Hospital.  Results Of the 41 patients who fit our criteria, 58% had no underlying ACTDs, 22% had systemic lupus erythematosus (SLE), and only 4% had other types of ACTDs.  Conclusion Chronic spontaneous urticaria is a frequent condition in SLE. We did not find a strong association between other ACTDs and chronic spontaneous urticaria.  



Antia C, Baquerizo K, Korman A, et al. Urticaria: A Comprehensive Review: Epidemiology, Diagnosis, and Work-Up. J Am Acad Dermatol. 2018 Oct;79(4):599-614. doi:10.1016/j.jaad.2018.01.020. PMID: 30241623

Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA²LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. Allergy. 2018 Jul;73(7):1393-1414. doi: 10.1111/all.13397.PMID: 29336054.

Confino-Cohen R, Chodick G, Shalev V, et al. Chronic urticaria and autoimmunity: associations found in a large population study. J Allergy Clin Immunol. 2012 May;129(5):1307-13. doi: 10.1016/j.jaci.2012.01.043. Epub 2012 Feb 14. PMID: 22336078.

Kolkhir P, Pogorelov D, Olisova O, et al. Comorbidity and Pathogenic Links of Chronic Spontaneous Urticaria and Systemic Lupus Erythematosus--A Systematic Review. Clin Exp Allergy. 2016 Feb;46(2):275-87. doi: 10.1111/cea.12673. PMID: 26545308.




How to Cite

Argobi Y. Chronic spontaneous urticaria in autoimmune connective tissue diseases. J Pak Assoc Dermatol [Internet]. 2022Apr.10 [cited 2024Jun.17];31(3):349-52. Available from:



Original Articles