Correlation between transepidermal water loss with proinflammatory cytokines in non-aging and aging group

Authors

  • Winawati Eka Putri Universitas Nahdlatul Ulama Surabaya
  • Meidyta Sinantryana
  • Hotimah Masdan Salim

Abstract

Background  Aging is a complex process and makes progressive loss of functional capacity of organ such as skin. Transepidermal water loss represents changes in skin permeability which happen in aging. There is an imbalance of immune system in aging. It can cause condition called inflammaging. Proinflammatory cytokines such as IL-6 and TNF-α were elevated in skin aging.  Purpose: This study aims to find correlation between TEWL and proinflammatory cytokines in non-aging and aging.  Methods  This research is an analytic observational study with cross sectional design. The IL-6 and TNF-α level were measured by using sandwich ELISA technique. TEWL was measured by Tewameter.  Results The mean value of IL-6 and TNF-α in both non-aging and aging group showed no significant difference. The TEWL in aging and non-aging group showed no statistically significant difference with IL-6 and TNF-α.   Conclusion  There was no significant relationship between TEWL and proinflammatory cytokines in non-aging and aging group.  

Downloads

Published

2022-04-10

How to Cite

1.
Putri WE, Sinantryana M, Salim HM. Correlation between transepidermal water loss with proinflammatory cytokines in non-aging and aging group. J Pak Assoc Dermatol [Internet]. 2022Apr.10 [cited 2024Jun.17];31(3):353-7. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1620

Issue

Section

Original Articles