Determination of red blood cell distribution width in patients with primary cutaneous vasculitis compared to systemic vasculitis

Authors

  • Farhana Wahab Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh
  • Mohammad Jamal Uddin Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh
  • ATM Asaduzzaman Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh
  • Mohammod Abu Hena Chowdhury Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh
  • Hasan Mahmud Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh
  • Rehnuma Nasim Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Keywords:

Red blood cell distribution width, Vaculitis, bsmmu

Abstract

Background :Red blood cell distribution width (RDW) has been considered as an inflammatory marker in various disorders.  Evaluation of RDW value can also be used as a novel and additional marker for differentiating systemic vasculitis from primary cutaneous vasculitis.Objective: To compare RDW value between patients with cutaneous vasculitis with systemic vasculitis , thereafter  to find out it's role as an effective indicator to distinguish both forms of vasculitis.Materials and methods: . This cross sectional observational study was conduct between from July 2016 to December 2017. Total of 48 patient were divided into primary cutaneous vasculitis and  systemic vasculitis. Blood was collected in EDTA tube to measure RDW value. Patient’s disease activity also scored and plotted according to Birmingham vasculitis activity score. Statistical analysis was performed by using SPSS.    Results: Significantly high mean RDW were  found in patients with systemic vasculitis compared to primary cutaneous vasculitis(15.09±0.92 vs. 13.48±1.1, p = 0.000). BVAS was significantly greater (13.93±5.10 vs. 4.87±2.69, p = < 0.001) in systemic vasculitis as well as in patients with high RDW group (11.73±5.71 vs. 5.37±3.96, p = < 0.001).  Optimal RDW cut off point for differentiating systemic vasculitis from cutaneous vasculitis was 14.2 with 81.3% sensitivity and 81.2% specificityConclusion: . Present study revealed importance of RDW monitoring along with disease activity in patients  with any form of vasculitis. Systemic vasculitis had higher level of RDW. So RDW can be considered as a marker to discriminate systemic vasculitis from primary cutaneous vasculitis

Author Biographies

Farhana Wahab, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Medical Officer,Kuwait Bangladesh Friendship Government Hospital, Dhaka

Mohammad Jamal Uddin, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Associate Professor,Dermatology Department ,Bangabandhu Sheikh Mujib Medical UniversityShahbag, Dhaka, Bangladesh

ATM Asaduzzaman, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Associate Professor,Dermatology Department ,Bangabandhu Sheikh Mujib Medical UniversityShahbag, Dhaka, Bangladesh

Mohammod Abu Hena Chowdhury, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Associate Professor,Dermatology Department ,Bangabandhu Sheikh Mujib Medical UniversityShahbag, Dhaka, Bangladesh

Hasan Mahmud, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Registrar,Dermatology DepartmentKurmitola General Hospital,Dhaka

Rehnuma Nasim, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh

Registrar,National Instituate of cancer research & hospital,Dhaka

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Published

2022-04-10

How to Cite

1.
Wahab F, Uddin MJ, Asaduzzaman A, Chowdhury MAH, Mahmud H, Nasim R. Determination of red blood cell distribution width in patients with primary cutaneous vasculitis compared to systemic vasculitis. J Pak Assoc Dermatol [Internet]. 2022Apr.10 [cited 2024Jun.17];31(3):334-41. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1619

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