Comparison of efficacy of liquid nitrogen and vitamin D3 in treatment of warts on hands and feet


  • Uzma Amin LGH
  • Hira Fatima
  • K Kehkshan t
  • Sameera Ali
  • Adnan Ali Saleem
  • Aneela Asghar


Cryotherapy, Human Papilloma Virus, Liquid nitrogen, Warts


Objective To compare the efficacy of intralesional vitamin D3 and cryotherapy in treatment of warts of hands and feet.   Methods A total of 100 patients of warts fulfilling the inclusion & exclusion criteria were enrolled in study who presented to Dermatology Department, Lahore General Hospital, Lahore. Patients were divided into two groups (A and B) with random number table leading to 50 patients in each group. Group A patients received liquid nitrogen cryotherapy (-196 ºC) while patients in group B were treated with intralesional vitamin D3 (5mg/ml). Patients in both groups were treated for 3 sessions at every 3 weeks interval. Treatment was labeled as efficacious if there was more than 50% reduction in wart size.   Results Mean age of patients was 23.72±14.10 years. 92% patients of group A showed efficacy while it was 84% in group B. Treatment was found to be efficacious in both groups and there was no statistically significant difference between these treatment modalities.   Conclusion Cryotherapy and intralesional vitamin D3 both are effective in treating palmoplantar warts.  

Author Biographies

Uzma Amin, LGH

Assistant professor, dermatology, LGH

Hira Fatima

Resident Dermatology

K Kehkshan t

Associate professor

Sameera Ali

Assistant professor

Adnan Ali Saleem

senior registrar

Aneela Asghar

Professor of dermatology


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How to Cite

Amin U, Fatima H, t KK, Ali S, Saleem AA, Asghar A. Comparison of efficacy of liquid nitrogen and vitamin D3 in treatment of warts on hands and feet. J Pak Assoc Dermatol [Internet]. 2021Aug.6 [cited 2024Feb.26];31(2):184-90. Available from:



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