Addison´s disease in a young child: A rare entity in children

Authors

  • Sadaf Amin
  • Zain Ali Raza
  • Nadia Ali Azfar
  • Muhammad Nadeem

Keywords:

Addison´s disease

Abstract

Addison's disease is an adrenocortical insufficiency due to the dysfunction or destruction of the entire adrenal gland. The disease usually manifests when 90% or more of both adrenal cortices are dysfunctional or destroyed affecting both glucocorticoid and mineralocorticoid functions. The morbidity and mortality associated with Addisons disease is relatively high due to delay in diagnosis and initiation of therapy. Here, we report a case of a seven years old child who presented to us with diffuse hyperpigmentation of the body, body flexures, palmar creases and mucosae. He was diagnosed with Addison´s disease, which is indeed a rare entity. In addition, this case report will also enhance the importance of cutaneous examination in suspecting Addison´s disease. 

References

Grossman AB. Thomas Addison and his disease. Grand Rounds 2004; 4: 8–9.

Sarkar SB, Sarkar S, Ghosh S, Bandyopadhyay S. Addison's disease. Contemp Clin Dent 2012; 3(4): 484-6.

Stewart PM, Krone NP. The adrenal cortex. In: Kronenburg HM, Melmed S, Polonsky KS, Reed Larson P, editors. Williams Textbook of Endocrinology. 12th ed. Philadelphia PA: Saunders Elsevier; 2011; 15(CH):515-20.

Cleveland BG. Adaptation to Addison’s disease in a Child: A Case Study. J Pediatr Health Care 2003; 17(6): 301-10.

Alebiosu CO, Odusan O. Addison’s disease: A case report. Annals of African Medicine 2003; 2: 85-7.

Parekh S, Melmane P, Bhate A, Khan A, Sarode A. Addison’s disease: A rare case report. IJSS 2016; 4(2): 268-71.

Soule S. Addison’s disease in Africa – A teaching hospital experience. Clin Endocrinol 1999; 50: 115-20.

Rochmah N, Faizi M. Addison’s disease in a child: A case report. Int J Pediatr Endocrinol 2015; 1: 40-2.

Downloads

Published

2020-09-30

How to Cite

1.
Amin S, Raza ZA, Azfar NA, Nadeem M. Addison´s disease in a young child: A rare entity in children. J Pak Assoc Dermatol [Internet]. 2020Sep.30 [cited 2025Mar.18];30(2):359-62. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1399

Issue

Section

Case Reports

Most read articles by the same author(s)

1 2 3 4 5 6 > >>