Methicillin resistant stahphylococcus aureus (MRSA) septicemia in pemphigus foliaceus - A coalition partners in resistant cases

Authors

  • Anuradha Jindal Dr. Anuradha Jindal M.D. dermatology, senior resident Dermatology department, Kasturba Hospital Manipal Academy of Higher Education, Manipal, Karnataka, India-576104 Email id – dr.anu17@gmail.com
  • Dr. Raghavendra Rao Dr. Raghavendra Rao M.D. dermatology, Additional Professor Dermatology department, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104 Email id – raghavrao1@gmail.com

Keywords:

MRSA, pemphigus foliaceus

Abstract

Infection contributes to considerable morbidity and mortality in patients with autoimmune bullous disorders (AIBDs) such as pemphigus. Increased susceptibility to infection in this population may occur via 3 primary mechanisms- defective barrier function as a result of blistering and subsequent erosions, down regulation of immunity due to medications used in the treatment of AIBDs and finally, immune dysregulation associated with autoimmunity.1 In pemphigus, sepsis is the most common cause of death, with staphylococcus aureus being the most frequently implicated organism.2 We hereby report two cases of methicillin resistant staphylococcus aureus (MRSA) septicemia in pemphigus foliaceus (PF) patients rendering them resistant to conventional immunosuppressive therapies. 

Author Biographies

Anuradha Jindal, Dr. Anuradha Jindal M.D. dermatology, senior resident Dermatology department, Kasturba Hospital Manipal Academy of Higher Education, Manipal, Karnataka, India-576104 Email id – dr.anu17@gmail.com

Dr. Anuradha Jindal M.D. dermatology, senior residentDermatology department, Kasturba HospitalManipal Academy of Higher Education, Manipal, Karnataka, India-576104Email id – dr.anu17@gmail.com

Dr. Raghavendra Rao, Dr. Raghavendra Rao M.D. dermatology, Additional Professor Dermatology department, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104 Email id – raghavrao1@gmail.com

Dr. Raghavendra RaoM.D. dermatology, Additional ProfessorDermatology department, Kasturba Medical College,Manipal Academy of Higher Education, Manipal, Karnataka, India-576104Email id – raghavrao1@gmail.com

References

Lehman JS, Murrell DF, Camilleri MJ, Kalaaji AN. Infection and Infection Prevention in Patients Treated with Immunosuppressive Medications for Autoimmune Bullous Disorders. Dermatol Clin. 2011; 29: 5 91-8.

A.R. Ahmed, R. Moy. Death in pemphigus. J Am Acad Dermatol. 1982; 7: 221–228.

Hammers CM, Stanley JR. Desmoglein-1, differentiation, and disease. J Clin Invest. 2013; 123: 1419-22.

Whittock NV, Bower C. Targetting of desmoglein 1 in inherited and acquired skin diseases. Clin Exp Dermatol.2003;28:410-5

Amagai M. Desmoglein as a target in autoimmunity and infection. J Am Acad Dermatol.2003; 48: 244-52.

Hanakawa Y, Stanley JR. Mechanisms of blister formation by staphylococcal toxins. J Biochem 2004; 136: 747-50.

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Published

2019-10-22

How to Cite

1.
Jindal A, Rao DR. Methicillin resistant stahphylococcus aureus (MRSA) septicemia in pemphigus foliaceus - A coalition partners in resistant cases. J Pak Assoc Dermatol [Internet]. 2019Oct.22 [cited 2025Jan.25];29(4):425-7. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1340

Issue

Vol. 29 No. 4 (2019): October - December

Section

Case Reports