Efficacy of platelet-rich plasma in the treatment of melasma: a pilot study


  • Farzana Faiz
  • Atif Shehzad
  • Rabia Farooq
  • Shaiqa Mufti
  • Asma Nasir
  • Tahir Jamil Ahmad


Platelet rich plasma, melasma


Objective To evaluate the efficacy of platelet-rich plasma (PRP) in patients with melasma attending the dermatology outpatient clinic of a tertiary care hospital. Methods We performed a therapeutic trial of 20 melasma patients having Fitzpatrick skin type, III, IV and V. Both male and female patients with mixed melasma were included in the study. The treatment included five fortnightly sessions of autologous PRP injections in the facial melasma.  Results were assessed by percentage reduction in baseline MASI score and by digital photography. The patients with baseline reduction in MASI score between 0 to 25% were labeled as showing mild response; 25-50% reduction fair response, 50-75% reduction good response and >75% reduction as excellent responders. The treatment trial was considered effective if there was greater than 50% reduction in MASI score from the base line. Results Of 20 enrolled patients with mixed melasma, 5 patients lost to follow-up. Mean age of the patients was 28 years. Of 15 evaluable patients, 2 (13.3%) patients showed good response, 9 (60%) patients showed fair response, and 4 (26.7%) patients poor response. None of patients showed excellent response. Conclusion Platelet-rich plasma may prove to be an effective adjuvant therapy for the treatment of melasma. 


Salim A, Rengifo-Pardo M, Vincent M. Melasma. In: Williams HC, Bigby M, editors. Evidence Based Dermatology. 2nd edn. London: Blackwell Publishing; 2008. P. 497-510.

Lapeere H, Boone B, Schepper SD. Hypomelanoses and hypermelanoses. In: Wolff K, Goldsmith LA, Katz SI, editors. Fitzpatrick’s Dermatology in General Medicine. 7th edn. Philadelphia: McGraw-Hill; 2008. P.622-40.

Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118:147e-159e.

Kim D, Park S, Park K. Transforming growth factor-β1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation. Int J Biochem Cell Biol. 2004;36:1482-91.

Yun WJ, Bang SH, Min KH, Kim SW, Lee MW, Chang SE. Epidermal growth factor and epidermal growth factor signaling attenuate laser-induced melanogenesis. Dermatol Surg. 2013;39:1903-11.

Ferrari M, Zia S, Valbonesi M, Henriquet F, Venere G, Spagnolo S et al. A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery. Int J Artif Organs. 1987;10:47-50.

Cho J, Kim S, Lee K. Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. Int J Mol Med. 2012;29:32-6.

Lacz N, Vafaie J, Kihiczak N, Schwartz R. Postinflammatory hyperpigmentation: a common but troubling condition. Int J Dermatol. 2004;43:362-5.

Domínguez E, Muñozledo F, Harcuch W. Growth factors and extracellular matrix proteins during wound healing promoted with frozen cultured sheets of human epidermal keratinocytes. Cell Tissue Res. 2002;307:79-89.

Shin K, Lee J, Lee S, Kim N. Platelet rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg. 2012;38:623-30.

Solano F, Briganti S, Picardo M, Ghanem G. Hypopigmenting agents: An updated review on biological, chemical and clinical aspects. Pigment Cell Res. 2006;90:550-71.

Yang G, Li Y, Nishimura E, Xin H, Zhou A, Guo Y et al. Inhibition of PAX3 by TGF-β modulates melanocyte viability. Mol Cell. 2008;32:554-63.

Cayirli M, Ercan C, Acikgoz G, Erbil A, Erturk G. Regression of melasma with platelet rich plasma treatment. Ann Dermatol. 2014;26:401-2.

Al-Shami S. Treatment of periorbital hyperpigmentation using platelet rich plasma injections. Am J Dermatol Venereol. 2014;3(5):87-94.

Yew C, Ramasamy T, Amini F. Response to intradermal autologous platelet rich plasma injection in refractory dermal melasma: Report of two cases. Available on





How to Cite

Faiz F, Shehzad A, Farooq R, Mufti S, Nasir A, Ahmad TJ. Efficacy of platelet-rich plasma in the treatment of melasma: a pilot study. J Pak Assoc Dermatol [Internet]. 2018Dec.13 [cited 2024Feb.26];28(3):355-60. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1268



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